Flexibility in fragmentation techniques with the Omnitrap

Flexibility in fragmentation technologies provides an extensive range of possible scientific experiments on existing mass spectrometric equipment and allows for much more comprehensivecharacterization of biomolecules than single fragmentation techniques alone. Since a couple of years, Fasmatech (Athens, Greece) is developing the Omnitrap, an upgrade to Thermo Fisher Scientific Exploris and QExactive systems providing a multitude of fragmentation technologies giving the system utmost versatility:

 

Ion Activation Arsenal for Tandem MSn

 

  • Slow heating and high energy CID
  • Electron Capture Dissociation
  • Electron Induced Dissociation
  • Electron meta-ionization
  • Dual-axis optical access for photo-dissociation using UVPD or IRMPD
  • External injection of activated neutrals and ion beams

The Omnitrap consists of a multi-segmented ion trap with multiple access points for fragmentation devices and has been selected as one of the most innovative innovations in 2018 by The Scientist. Its development is part of the EU-funded TopSpec project for developing technology for comprehensive monoclonal antibody characterization.

Omnitrap layout

Performance Achievements of the Omnitrap

 

  • Access to an extended mass range using variable frequency rectangular RF waveforms for trapping ions
  • Highly efficient ECD and EID of precursor ions in high vacuum with fine-tuned electron beam energy
  • Enhanced CID efficiency in pulsed RF elds at elevated gas pressure
  • Lossless transfer of ions between the QExactive instrument and the Omnitrap processing platform

 

Omnitrap Application Areas

 

  • Top-down proteomics, proteoform and post-translation modification analysis
  • Structural biology
  • Native mass spectrometry
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