Please click on the links below to download further information:

Product information:

• • High Mass Synapt system
  • IPT SampleStream
  • Pre-owned systems
  • Training courses
  • Service contracts
  • Overview on supported instruments

Product Data Sheets:

• PhotoSynapt Product Data Sheet

White papers:

• Purchase of pre-owned software licenses
• Understanding CID fragmentation

Posters and presentations:

• “Coupling ECD with IMS and native MS on a Waters Quadrupole-IMS-TOF mass spectrometer”, M. Macht et al., Oral presentation at IMSC 2022
  
• “Hyphenating Ion Mobility and Action Spectroscopy in a Synapt G2 to Probe the Structure and Kinetics of Aggregating Peptides”, Steven Daly, Oral presentation at IMSC 2022
• “A Compact, High.Resolution Time-of-Flight Mass Spectrometer Based on and Electrostatic Analser”, Steven Daly et al., Poster at IMSC 2022
• “Hyphenation of Ion Mobility Mass Spectrometry and Action Spectroscopy to Probe Structure and Kinetics of Peptide Aggregation”, Sjors Bakels et al., Poster at IMSC 2022
• “Top-down fragmentation of the native tetrameric 102kDa Concanavalin A complex using ECD on a QTOF system”, M. Macht et al., Poster at DGMS 2023

Peer-reviewed Articles:

• Analysis of AAV using high mass ESI:
  Molecular weight determination of adeno-associate virus serotype 8 virus-like particle either carrying or lacking genome via native nES gas-phase electrophoretic molecular mobility analysis and nESI QRTOF mass spectrometry
  Samuele Zoratto, Victor U. Weiss, Jerre van der Horst, Jan Commandeur, Carsten Buengener, Alexandra Foettinger-Vacha, Robert Pletzenauer, Michael Graninger, Guenter Allmaier; JMS 2021, https://doi.org/10.1002/jms.4786 (open access)
• non-covalent analysis using high mass ESI:
  Processing of the SARS-CoV pp1a/ab nsp7–10 region
  Boris Krichel, Sven Falke, Rolf Hilgenfeld, Lars Redecke, Charlotte Uetrecht; Biochem J. 2020 Mar 13; 477(5): 1009–1019, doi: 10.1042/BCJ20200029 (open access)
• non-covalent analysis using high mass ESI:
  Structural analysis of ligand-bound states of the Salmonella type III secretion system ATPase InvC
  Ivonne Bernal, Jonas Römermann, Lara Flacht, Michele Lunelli, Charlotte Uetrecht, Michael Kolbe; Prot. Sci. 2019 Oct;28(10):1888-1901. doi: 10.1002/pro.3704. (open access)
  
• non-covalent analysis using high mass ESI:
  A strategy for the identification of protein architectures directly from ion mobility mass spectrometry data reveals stabilizing subunit interactions in light harvesting complexes
  Margit Kaldmäe, Cagla Sahin, Mihkel Saluri, Erik G. Marklund, Michael Landreh; Prot. Sci. 2019 (28) 1024–1030, DOI: 10.1002/pro.3609 (open access)
  
• non-covalent analysis using high mass ESI:
  Towards the molecular architecture of the peroxisomal receptor docking complex
  Pascal Lill, Tobias Hansen, Daniel Wendscheck, Bjoern Udo Klink, Tomasz Jeziorek, Dimitrios Vismpas, Jonas Miehling, Julian Bender, Andreas Schummer, Friedel Drepper, Wolfgang Girzalsky, Bettina Warscheid, Ralf Erdmann, Christos Gatsogiannis; PNAS 2020, 117 (52) 33216-33224; https://doi.org/10.1073/pnas.2009502117 (open access)
• tau phosphoprotein analysis using high mass ESI:
  A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications
  Friedel Drepper, Jacek Biernat, Senthilvelrajan Kaniyappan, Helmut E Meyer, Eva Maria Mandelkow, Bettina Warscheid, Eckhard Mandelkow; J. Biol. Chem. 2020 Dec 25;295(52):18213-18225. doi: 10.1074/jbc.RA120.015882 (open access)
• crosslink analysis using high mass ESI:
  Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
  Caroline Haupt, Tommy Hofmann, Sabine Wittig, Susann Kostmann, Argyris Politis, Carla Schmidt; J Vis Exp. 2017; (129): 56747, doi: 10.3791/56747 (open access)
• MS SPIDOC:
  Coherent diffractive imaging of proteins and viral capsids: simulating MS SPIDOC
  Thomas Kierspel, Alan Kadek, Perdita Barran, Bruno Bellina, Adi Bijedic, Maxim N. Brodmerkel, Jan Commandeur, Carl Caleman, Tomislav Damjanović, Ibrahim Dawod, Emiliano De Santis, Alexandros Lekkas, Kristina Lorenzen, Luis López Morillo, Thomas Mandl, Erik G. Marklund, Dimitris Papanastasiou, Lennart A. I. Ramakers, Lutz Schweikhard, Florian Simke, Anna Sinelnikova, Athanasios Smyrnakis, Nicusor Timneanu & Charlotte Uetrecht for the MS SPIDOC Consortium; Analytical and Bioanalytical Chemistry volume 415, pages4209–4220 (2023)

Tech tipps series literature:

• Tech Tipps part I – Common contaminants in LC-MS
• Tech Tipps part II –  Data storage and backup
• Tech Tipps part III – Temperature effects on electronics
• Tech Tipps part IV – LC column cleaning
• Tech Tipps part V –  Installing MassLynx under Windows 10