Literature
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Product information:
- High Mass Synapt system
- ECD upgrade for Synapt systems
- ECD upgrade for QExactive systems
- Pre-owned systems
- Training courses
- Service contracts
- Overview on supported instruments
White papers:
- ECD – General information
- Differentiation of Asp and isoAsp residues by electron-capture dissociation (ECD)
- ECD for top-down analysis
- ECD and ion mobility
- Purchase of pre-owned software licenses
IMSC 2022 Maastricht contributions:
- “Coupling ECD with IMS and native MS on a Waters Quadrupole-IMS-TOF mass spectrometer”, M. Macht et al., Oral presentation
- “Hyphenating Ion Mobility and Action Spectroscopy in a Synapt G2 to Probe the Structure and Kinetics of Aggregating Peptides”, Steven Daly, Oral presentation
- “A Compact, High.Resolution Time-of-Flight Mass Spectrometer Based on and Electrostatic Analser”, Steven Daly et al., Poster presentation
- “Hyphenation of Ion Mobility Mass Spectrometry and Action Spectroscopy to Probe Structure and Kinetics of Peptide Aggregation”, Sjors Bakels et al., Poster presentation
Peer-reviewed Articles:
- Analysis of AAV using high mass ESI:
Molecular weight determination of adeno-associate virus serotype 8 virus-like particle either carrying or lacking genome via native nES gas-phase electrophoretic molecular mobility analysis and nESI QRTOF mass spectrometry
Samuele Zoratto, Victor U. Weiss, Jerre van der Horst, Jan Commandeur, Carsten Buengener, Alexandra Foettinger-Vacha, Robert Pletzenauer, Michael Graninger, Guenter Allmaier; JMS 2021, https://doi.org/10.1002/jms.4786 (open access) - non-covalent analysis using high mass ESI:
Processing of the SARS-CoV pp1a/ab nsp7–10 region
Boris Krichel, Sven Falke, Rolf Hilgenfeld, Lars Redecke, Charlotte Uetrecht; Biochem J. 2020 Mar 13; 477(5): 1009–1019, doi: 10.1042/BCJ20200029 (open access) - non-covalent analysis using high mass ESI:
Structural analysis of ligand-bound states of the Salmonella type III secretion system ATPase InvC - non-covalent analysis using high mass ESI:
A strategy for the identification of protein architectures directly from ion mobility mass spectrometry data reveals stabilizing subunit interactions in light harvesting complexes
Margit Kaldmäe, Cagla Sahin, Mihkel Saluri, Erik G. Marklund, Michael Landreh; Prot. Sci. 2019 (28) 1024–1030, DOI: 10.1002/pro.3609 (open access) - non-covalent analysis using high mass ESI:
Towards the molecular architecture of the peroxisomal receptor docking complex
, , , , , , , , , , , , , - tau phosphoprotein analysis using high mass ESI:
A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications
Friedel Drepper, - crosslink analysis using high mass ESI:
Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
Caroline Haupt, Tommy Hofmann, Sabine Wittig, Susann Kostmann, Argyris Politis, Carla Schmidt; J Vis Exp. 2017; (129): 56747, doi: 10.3791/56747 (open access) - ECD-based fragmentation of antibodies using QExactive:
Generating Informative Sequence Tags from Antigen-Binding Regions of Heavily Glycosylated IgA1 Antibodies by Native Top-Down Electron Capture Dissociation
Jean-Francois Greisch, Maurits A. den Boer, Frank Beurskens, Janine Schuurman, Sem Tamara, Albert Bondt, Albert J. R. Heck; J. Am. Soc. Mass Spectrom. 2021, 32, 6, 1326–1335, https://doi.org/10.1021/jasms.0c00461 (open access)
Tech tipps series white papers: