The European XFEL has just entered user operation. With its unparalleled peak brilliance and repetition rate, European XFEL has the potential to further applications in single particle imaging (SPI), thus far limited to large viral particles at X-ray fee-electron lasers (XFEL). SPI will allow imaging protein complexes without the need for crystallization. This eventually renders transient conformational states accessible for high resolution structural studies, yielding molecular movies of biomolecular machines. A major bottleneck is the wealth of data required to reconstruct a single structure leading to long processing times. This is currently also a problem in electron microscopy (EM). MS SPIDOC will overcome this data challenge by developing a native mass spectrometry (MS) system for sample delivery called X-MS-I. It will provide mass- and conformation-selected biomolecules that are oriented along their dipole axis upon imaging. This will enable structural reconstruction from much smaller datasets, speeding up the analysis time tremendously. Moreover, the system features low sample consumption and a controlled low background, easing pattern identification.