Pre-owned refurbished Instruments
At MS Vision we also sell and buy pre-owned lab equipment, in particular mass spectrometry systems from Waters, Thermo Fisher and Sciex. Whether you are looking for a high resolution mass spec system or a new triplequad/QqQ/Qtrap for quantitation: all our systems are checked and refurbished in-house, specified at manufacturers specifications and shipped and installed by specialized movers and our own experienced service specialist. Every system comes with installation and a 3 months warranty, longer warranties are available on request as well.
Buying a used LC-MS- or mass spectrometry system has several advantages:
Apart from being more eco friendly, our pre-owned mass spectrometer offer you a much better return of investment due to lower purchasing costs than new systems. As these systems are also proven in their usage, you can easily find established methods, the software compatibility to your existing instruments is ensured and the shortcomings of a particular model are already known.
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Currently available pre-owned systems:
All our instruments are sold including shipment, installation and three months warranty. Longer warranty is available on request. If you need items such as nitrogen generators, instrument benches or noise insulations please let us know and we can check whether we have something suitable for you.
The SYNAPT G2-S incorporates both high-sensitivity Waters StepWave™ ion transfer optics and Triwave® ion mobility technologies along with a suite of new informatics tools to take qualitative and quantitative high resolution performance to a new level.
SYNAPT G2-S provides a 30X improvement in signal intensity for mass spectral peaks, better than a 5X improvement in signal-to-noise, and up to a 10-fold improvement in limits of quantitation over previous-generation mass spectrometers. The significant increase in sensitivity, together with the unrivalled selectivity and analytical peak capacity made possible by ion mobility separations, allows the SYNAPT G2-S to identify and quantify sample analytes at lower concentrations than any other high resolution mass spectrometer and easily and routinely reveal details about complex samples that were previously difficult or impossible to obtain.
StepWave ion-transfer optics technology employs a revolutionary off-axis design for dramatically increasing the efficiency of ion transfer from the ion source to the MS analyzer, while at the same time actively eliminating undesirable neutral contaminants. The resulting sensitivity improvement is critical, for example, in metabolite identification where the goal is to find, identify and quantify all metabolites in a sample.
The instrument is equipped with a 4k quadrupole and currently installed and running in our lab in Almere.
| Specifications | |
| TOF Mass Resolution | >20.000 FWHM @ m/z 956 in resolution mode, >40.000 FWHM in high resolution mode |
| Mass range | 20 – 100.000 m/z in resolution mode, 20 – 32.000 m/z in high resolution mode |
| Quadrupole mass range | 20 – 4.000 m/z |
| Quadrupole transmission in non-resolving mode | 20 – 16.000 m/z for 4k quadrupole |
| Mass accuracy | better than 1 ppm RMS with internal lockmass calibration |
| Acquisition rate | Up to 30 Hz |
| Dynamic range | at least 4 orders of magnitude |
| Measurement modes | DDA, DIA (MS(E), IMS-TOF |
| MS to MS/MS switching time | 5 ms |
| IMS functions | Separation of ions based on their mobility Time Aligned Parallel (TAP) fragmentation Drift time measurements |
The Waters Xevo QTOF G2-XS mass spectrometer is a new high-performance benchtop quadrupole time-of-flight (QTof) mass spectrometer. Featuring the new XS Collision Cell, the Xevo G2-XS QTof stands alone among its peers in offering uncompromised analytical sensitivity and selectivity in a benchtop QTof mass spectrometer. The Xevo G2-XS QTof mass spectrometer combines the new XS Collision Cell with the proven, signature technologies of Tof-MRM, StepWave, and QuanTof to deliver optimum levels of robust sensitivity and selectivity, resulting in the detection of more low-level compounds than ever before. For targeted quantitative experiments, Tof-MRM mode delivers a 10-fold improvement in signal-to-noise when compared with full scan mode, resulting in limits of detection and quantification that completely redefine expectations for a benchtop high-resolution mass spectrometer.
The instrument has a new PC and a new scroll pump and is currently installed at a customer site and will be collected in October 2024.
| Specifications | |
| TOF Mass Resolution | >40.000 FWHM @ m/z 956 in resolution mode, >30.000 FWHM in sensitivity mode |
| Mass range | 20 – 100.000 m/z |
| Quadrupole mass range | 20 – 4.000 m/z in resolving mode |
| Quadrupole transmission in non-resolving mode | 20 – 16.000 m/z |
| Mass accuracy | better than 1 ppm RMS with internal lockmass calibration |
| Acquisition rate | Up to 30 Hz |
| Dynamic range | at least 4 orders of magnitude |
The Waters Xevo TQ-S Mass Spectrometer is an advanced, bench-top, tandem quadrupole mass spectrometer designed for ultra high performance LC-MS applications. Unlike conventional tandem quadrupole mass spectrometers, the Xevo TQ-S utilizes unique T-Wave and ScanWave enabled collsion cell technology to provide a highly flexible analytical tool capable of supporting both quantitative and qualitative studies on a single MS platform. In addition, the stepwave ion transfer improves transfer of the generated ions, keeps neutrals out and the instrument clean even with demanding samples. The Xevo TQ-S is a robust platform for quantitative LC-MS/MS, featuring high speed MRM, with enhanced full scan spectral acquisition modes providing additional qualitative LC-MS/MS capabilities.
| Specifications | |
| Mass range | 2 – 2.048 m/z |
| Scan speed | Up to 10.000 Da/s |
| Mass stability | less than 0,05 amu over 24h |
| Linearity of response | >five orders of magnitude from the limit of detection |
| Polarity switching time | 20 ms between positive and negative mode |
| MS to MS/MS switching | 3 ms |
| MRM acquisition rate | Minimum dwell time of 1 ms per MRM channel |
| Number of MRM channels | Up to 16.384 MRM channels |
| Aquisition | Full scan MS Product ion scan (ScanWave enhanced) Precursor ion scan Constant neutral loss scan Selected ion monitoring (SIM) Multiple reaction monitoring (MRM) |
| Mass resolution | Automatically adjusted to desired resolution (0.40 Da, 0.75 Da or 1.00 Da FWHM) |
| MRM sensitivity (ESI+) | 1 pg reserpine on-column S/N>300.000:1 |
The ThermoFisher Exploris 480 is a Thermo Scientific™ quadrupole-Orbitrap™ mass spectrometer, based on the hardware and instrument control software designs of the next-generation Thermo Scientific™ mass spectrometers and incorporates extensive customer and service engineer feedback.
Built on the guiding principle of ease-of-use and reliable hardware, robust system performance boosts sample throughput. Soundness of data is assured with high-resolution accurate-mass (HRAM) selectivity, high scan speed and bestin-class mass spectral quality, all within a compact footprint to conserve bench space.
Simplified operation, smart scheduling and execution of user selected scan types deliver rich, high-confidence sample insights for users of all skill levels in a wide range of applications from small molecules to peptides and intact proteins.
Features:
- Ultimate sensitivity with an efficient, heated electrospray ionization (H-ESI) sprayer to deliver maximum performance with minimal optimization
- Flow rates from 1–1,000 µL/min:
– low flow needle 1–10 µL/min
– high flow needle 10–1,000 µL/min - Enhanced ruggedness and reduced chemical noise with sweep gas
The instrument is currently located in our office in Almere, tested and running under vacuum.
| Specifications | |
| Mass range | 40 – 6.000 m/z |
| Resolution | 480.000 at m/z 200 |
| Scan rate | up to 40 Hz |
| Mass accuracy | internal <1 ppm RMS, external <3ppm RMS |
| Polarity switching | One full cycle in <700 msec (one full positive mode scan and one full negative mode scan at a resolution setting of 60,000) |
| Dynamic range | >5000:1 |
| Multiplexing | Up to 20 precursors per scan |
| Sensitivity | Full MS: 50 fg reserpine on column S/N 100:1 SIM: 50 fg reserpine on column S/N 100:1 |
- Ultra-High-Field Orbitrap (HF) mass analyzer for faster scan speed and higher resolution
- Advanced Quadrupole Technology (AQT) improves precursor selection and transmission for more accurate quantitation of low abundant analytes in complex matrices
- Sophisticated Data-Independent Acquisition (DIA) and Parallel Reaction Monitoring (PRM) deliver reproducible quantitation with complete qualitative confidence
- The Advanced Active Beam Guide (AABG) reduces noise and improves instrument robustness
- Optional intact Protein Mode provides superior trapping of large molecules for improved analysis of intact proteins
| Specifications | |
| Mass range | 50 – 6.000 m/z |
| NativeQE mass range | 50 – 10.000 m/z |
| NativeQE Quad selection limit | 10.000 m/z |
| Resolution | 240.000 at m/z 200 |
| Scan rate | up to 18 Hz |
| Mass accuracy | internal <1 ppm RMS, external <3ppm RMS |
| Polarity switching | One full cycle in <1 sec (one full positive mode scan and one full negative mode scan at a resolution setting of 60,000) |
| Dynamic range | >5000:1 |
| Multiplexing | Up to 10 precursors per scan |
| Sensitivity | Full MS: 500 fg buspirone on column S/N 100:1 SIM: 30 fg buspirone on column S/N 100:1 |
Currently we have two nanoAcquity systems and one I-Class system available
Acquity series has set a new standard in liquid chromatography, introducing the UPLC technology, which has been adopted successfully in laboratories around the world for the most demanding separations. Acquity UPLC systems are extremely robust, dependable, and reproducible.
- Work at higher efficiencies with a much wider range of linear velocities, flow rates, and backpressures
- Higher flow rates and increased throughput result in superior resolution and sensitivity
- Eliminate significant time and cost per sample, while improving quality of results
In the case an LC system is purchased, in combination with an MS system, a 10 % discount will be applied on the purchase price of the HPLC.
MS Vision has this several complete Acquity UPLC stacks on offer, comprising the following hardware & software components:
| Acquity Systems available | |
| Acquity I-Class | Binary solvent manager, Sample Manager FTN, Column Manager, Sample Organizer |
| Nano Acquity | Binary solvent manager, Sample Manager |
| Nano Acquity | Binary solvent manager, Sample Manager |
| Nano Acquity | Binary solvent manager, Aux pump, Sample Manager |
The systems will be delivered complete and ready to directly accept installation. The Acquity forms an ideal platform in combination with the following mass specs, also on offer: Synapt series, XEVO Q-ToF series and the Q-ToF Premier.
If purchased, in combination with an MS system, a 10 % discount is applicable on the purchase price of the LC system.
Currently we have one Ultimate3000 system available
The ThermoFisher Ultimate 3000 series is a workhose system for Proteomics. It allows for flexible configurations with or without separate loading pumps, preconcentration as well as 2D setups.
| U3000 Systems available | |
| U3000 Nano with separate loading pump | FLM-3100B biocompatible nano flow manager, DGP-3600MB biocompatible micropump, WPS-3000 TBPL nano biocompatible well plate autosampler |
The systems will be delivered complete and ready for installation. The U3000 forms an ideal platform in combination with the following mass specs: ThermoFisher LTQ-Orbitrap, QExactive, Exploris series or Tribrid systems. Also Bruker QTOF systems can be easily connected to the U3000 via Brukers HyStar software.
If purchased, in combination with an MS system, a 10 % discount is applicable on the purchase price of the LC system.
Why buying used mass spectrometers from MS Vision?
When buying a pre-owned mass spectrometer from MS Vision, you’ll get much more than just a box. Our approach is to sell quality!
What does this mean?
It means we take care of everything. You buy the system and get it delivered, installed on site, if necessary you can get a familiarization and we also take care of warranty and after sales support. We always sell a package of shipment, installation and warranty as we genuinely believe into the equipment we sell and we do not want to leave you alone with any issues potentially arising after installation. And we will not sell you an instrument for which we cannot provide the full range of support! That also means we only handle used mass spectrometers and complete LC-MS systems from Waters, Sciex and ThermoFisher. No Bruker, Agilent or Shimadzu mass spec systems, no ICP-MS, no GC-MS, no MALDI-MS. All the pre-owned systems we sell are fully supported by us and usually located in Europe as we exclusively operate in Europe.
That also means that our prices sometimes are higher when you compare it to deals on Ebay or bidding platforms. However, there you often bid on instruments in US or Asia and you do not really know the status. So bringing these instruments to Europe means you pay a couple of thousand Euros for transportation, ~20%VAT and you have to take care of installation (usually another few thousand Euros). These additional costs can add up to 20-25 k€ for a 50 k€ instrument and suddenly the deal is not that great anymore. When buying from MS Vision you know the costs upfront. And warranty from a dealer in US or China? Usually not. If something doesn’t work you’re on your own. In addition, mass spectrometers are often categorized as so-called dual use items. That means for export, in particular form US, there is a lot of paperwork involved including end-user certificates, etc. Do you want to risk all that with a 50-200k€ investment?
In a recent case we also saw prices for pre-owned Waters nanoAcquity LC’s of around 15-18k€. Sounds like a good deal? Well, what you need to know is that just the PM kits for the two pumps and the autosampler are sold by Waters for almost 15k€. That means the wear parts in these system can’t have been replaced as otherwise there is zero chance to make this price sensible… So be careful when looking at very low prices for pre-owned equipment! There is still a price to pay…
For buying systems, we are currently primarily interested in the following models of used mass spectrometers or complete LC-MS systems:
Waters:
- Synapt G2/G2-S/G2-Si
- Xevo TQ-S/TQ-XS
Sciex:
- 5500 QT/API
- 6500 QT/API
- 6500+ QT/API
ThermoFisher:
- Q Exactive classic/plus/HF
- We are not buying or selling LTQ Orbitrap classic/focus/Velos/Velos Pro instruments anymore! These systems turned out to be to unstable once decomissioned and re-installed. However, we are fully supporting running systems for the foreseeable future. LTQ Orbitrap Elite systems are sometimes bought as spare parts donors.
Contact us via the contact form or send us an email at info@msvision.com!